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They decrease the production of IL-6, TNF-, and IL-1-, and inhibit cyclooxygenase-2 (Cox-2), inducible nitric oxide synthase (iNOS) responsible for inflammation [75]

Therefore, DHODH has emerged as a potential regulatory hub, where its inhibition may enhance ferroptotic cell death, offering a novel angle for therapeutic intervention, particularly in cancers such as pancreatic adenocarcinoma (175) and breast cancer (176), where certain cells show resistance to other forms of cell death (171,177)

Davies MN, OCallaghan BL, Towle HC (2008) Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity

2 B , D , and F )

"Schedule I"

Cn nhng ngi b huyt p cao, b sung vitamin C gip gim huyt p tm thu 4.9 mmHg v huyt p tm trng 1.7 mmHg