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Again, given the emerging role of tryptophan and its metabolites in immune function, Trp conversion into indole-3-acetaldehyde and then indole-3-acetate, represents a mechanism by which the gut microbiome potentially influences the development of axSpA 77

However, studies examining effects of both glutamine and glutamate demonstrated differential effects of these FAAs on functions of IECs and intestinal morphology

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People taking immunosuppressant medications or sedatives should consult with their practitioner in regards to any potential contrary effects

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Front Cell Dev Biology, 2021, 9