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ROS is a product of cellular redox metabolism, and moderate amounts of ROS in the epididymis can play a role in sperm maturation and capacitation by regulating cAMP levels (Taylor et al., 2013)

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A placebo-controlled phase 2 RCT testing pimavanserin in 117 PD patients with moderately severe ICDs has been completed but results have not yet been made public (PIMPARK study, NCT03947216)