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*Correspondence: Tarique Hussain, [email protected]

It can also provide a temporary boost in alertness and focus, thanks to its caffeine content. Not all coffee is created equal

Health is the highest good of man

Cyclic dimeric guanosine monophosphate (c-di-GMP) is an ubiquitous second messenger found in many prokaryotes such as Mycobacterium tuberculosis, Vibrio cholerae , or Salmonella enterica that regulates a wide span of physiological processes including bacterial protein secretion, multicellular behaviour, virulence, motility, and cell development and differentiation [Citation112,Citation113]

Ignoring them can turn a manageable issue into an emergency

doi: 10.1016/j.arr.2018.04.004 41 TekerH