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Therefore, we have emphasized the crucial role of the CS and its fine-tuned regulation, which is both enzymatic- and miRNA-dependent, as the primary factor in metabolic cancer flexibility

Nucleic Acids Research

In pediatric patients, 1 - 3 mEq/kg infused over 4 - 8 hours is customary, but neonates should receive 4.2 % solutions at rates no greater than 8 mEq/kg/day to avoid intracranial hemorrhage

Before the target cells can use the fatty acids for ATP production and oxidation, the fatty acids with chain lengths of 14 or more carbons must be activated and subsequently transported into mitochondrial matrix of the cells in three enzymatic reactions of the carnitine shuttle

Sodium benzoate and sodium phenylacetate are ammonia scavengers that bypass the urea cycle by conjugation of benzoate with glycine to generate hippurate, and of phenylacetate with glutamine to generate phenylacetylglutamine, which are then excreted in urine

TABLE 2 ESCM with both direct and indirect effects on the PI3K/Akt pathway and their indications