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The interconnection between the root canal system and periradicular tissues through the apical foramen and foramina enables the spread of intracanal infections to these tissues (Sehirli et al., 2019)

Donini LM, Poggiogalle E, Piredda M, et al

References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

Top-Down Approach The top-down approach used macro-level indicators: Parent market benchmarks Global/regional industry trends Economic indicators (GDP, demographics, spending patterns) Penetration and usage ratios This approach was used for segments where granular data were limited or inconsistent

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