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However, an impairment in the respiratory burst was observed in granulocytemacrophage colony-stimulating factor (GM-CSF)-matured MDMs and alveolar macrophage-like (AML) cells 2 from both patients with TNF deficiency, TNF- or TNFR1-deficient induced pluripotent stem (iPS)-cell-derived GM-CSF-matured macrophages, and healthy control MDMs and AML cells differentiated with TNF blockers in vitro, and in lung macrophages treated with TNF blockers ex vivo

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Furthermore, ETC deficiencies are noted in the subunits that are encoded by the mitochondrial DNA, specifically in the ETC Complex III (Poling et al., 2006)

Zinchuk VV, Pronko TP, Lis MA