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Some individuals also opt for one-time B12 shots to give themselves an extra boost during particularly busy or stressful times in their lives.

For keeping vitamin B12 levels up, a common dose is 1000 mcg (1 mg) once a month

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A 2024 paper in Diabetes, Obesity and Metabolism found a similar small-molecule inhibitor dose-dependently limited body weight and fat mass gains, improved oral glucose tolerance and insulin sensitivity in obese mice [2]