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Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals

In animal models, 1-methyl-4-phenol-1,2,5,6-tetrahydropyridine (MPTP) is used to induce destruction of dopaminergic neurons in the substantia nigra, mimicking human Parkinsons-like syndrome (111), while the infusion of BHB was found to have a protective role in dopaminergic neurodegeneration and motor deficits induced by MPTP (112)

Acknowledgements The authors thank Debra Weingarten for her editorial assistance in the preparation of this manuscript

Although this discovery is from two decades ago, the molecular basis of Parkinsons disease is still unknown

J Biol Chem 264:98149819 Tortora L, Ruha AM, Ramos KS, Jaeschke H, Rumack BH, Kang AM, Padilla-Jones A, Wilhelms K, Curry SC (2018) Pharmacogenomic analysis of a patient with severe hepatotoxicity and hemolysis after acetaminophen overdose despite early N -acetylcysteine therapy (abstract)

Cancer 75 , 154163 (2023)