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4-HNE-Mediated Mitochondrial Dysfunction While 4-HNE displays targeting of many cellular components, proteins, and cell types, mitochondria are a prominent target of its toxic activity (13, 20)

The brain has a high level of metabolic activity therefore also has high levels of mitochondrial activity

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Data of panels a,b,d , g,h,i are mean values standard deviation of three independent replicates

Because of this effect on MAO-A, the use of intravenous methylene blue has been associated with the development of serotonin syndrome 1-8