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If you are using a liposomal format, this is less of a concern, but water remains the gold standard

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They include various free radicals and reactive molecules formed from molecular oxygen and nitrogen, including superoxide anion radical (O ), hydroxyl radical (OH ), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ), nitric oxide (NO), and peroxynitrite (ONOO ) [28]

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In vitro results showed that HP55-coated capsules reduced insulin release at pH 1.2 from 90 to 10%

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doi: 10.1007/BF02539413 265 DonaldsonPJGreyACMaceo HeilmanBLimJCVaghefiE

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