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Pharmacological modulation of PI3K/PTEN/Akt/mTOR/ERK signaling pathways in ischemic injury: A mechanistic perspective

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In research focused on the nervous system, GHK has demonstrated neuroprotective effects in models of neurodegenerative diseases and improved tissue regeneration

Of interest here is the recent description that AMP-activated protein kinase (AMPK), a hypothalamic enzymatic complex involved in the hypothalamic control of energy and metabolic homeostasis, and activated by ghrelin, participates in the control of GH secretion, as its blocking or its functional impairment inhibits ghrelin- or GHRH-induced GH secretion, most likely by increasing SS tone (88)