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Four out of the nine included studies had an unclear or moderate risk of bias, which may have impacted the reliability of the results

These results prove that this polymer, based on the CMT strategy, can cross the BBB and thus has excellent application prospects in the treatment of neurological diseases, including PD

Ion exchange chromatography is another widely used technology that separates molecules based on their electric charge under specific pH and temperature conditions

Potential pathophysiological mechanisms involve, among others, neuro-immune dysregulation

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CYANOKIT solutions should be visually inspected for particulate matter and color prior to administration Discard solution if particulate matter is present or solution is not dark red Infuse Vial: Use vented intravenous tubing, hang and infuse over 15 minutes