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65, 66, 67, 70, 71 Importantly, it is now clear that the cytostatic/cytotoxic effects of CDDP do not represent a mere consequence of its genotoxic activity, but originate from both nuclear and cytoplasmic signaling pathways

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baicalensis alleviated the damage through multiple mechanisms, such as the reduction of inflammatory factors, the activation of antioxidant pathways and the regulation of relevant signaling pathways (Figure 3)

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