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Notably, liquid biopsy has the potential to overcome several key limitations of conventional tissue biopsy, which are particularly relevant to CNS radiotherapy

A variety of modeling approaches ranging from empirical to more complex systems modeling approaches have been applied to characterize circadian biology and its influence on drug actions, optimize time of dosing, and identify opportunities for pharmacological modulation of the clock mechanisms and their downstream effects

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Animal studies employed still different approaches scaled by body weight

13,14 While existed reviews have addressed the general application of nanotherapeutics in PD, 15 this review specifically focuses on how engineered nanoparticles can be directed toward distinct subcellular organelles to restore their function and alleviate dysfunction-related pathology