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[12] Contemporary reporting described the death as a myocardial infarction occurring in a participant who had received the eleventh weekly dose, and the trials attending physician considered the most likely explanation to be pre-existing asymptomatic coronary artery disease rather than the study drug

doi: 10.1038/s41594-017-0011-7 68 RioboNAManningDR

The top 2-cm of soil containing root mats and other plant detritus was discarded

Given its significant role in brain health and neurotransmitter signalling, low levels of B12 can affect mood regulation, contributing to feelings of sadness or lack of motivation