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Additionally, significant dietary restriction and reduced intake of animal productscommon with appetite suppressionmay decrease dietary B12 consumption

doi:10.7326/M19-0830

B12 was found to be particularly effective in treating post-herpetic neuralgia, alcohol-related neuropathy and diabetic neuropathy 5

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The reaction is more common in oral dosing protocols ranging from 100 to 500 micrograms per day and tends to resolve with dose adjustment

These were tested first in the statistical testing hierarchy, followed by the confirmatory secondary endpoints, which were tested in the following order: achievement of weight loss of at least 10% or 15% at week 104