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In a study of 134 older adults, GDNF levels decreased in Alzheimers patients, especially those with cognitive impairments

ROS imbalance represents another vulnerability associated with mtDNA mutation-induced dysfunction

Furthermore, vitamin C (at a concentration of 3 mg/mL) helps shift macrophage polarization from the pro-inflammatory M1 phenotype to the reparative M2 phenotype (as shown in vitro), which is important in controlling inflammation and promoting tissue healing [119]