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Endothelial dysfunction may lead to impaired vasoconstriction, affecting microcirculatory blood flow, exacerbating tissue perfusion deficits in septic patients, and ultimately resulting in multi-organ failure

For example, reduced EAAT2 activity leads to elevated extracellular glutamate concentrations [309, 310], which trigger excessive calcium influx into both neurons and astrocytes

The elimination of organelles evolved to provide more space for oxygen-carrying hemoglobin and to maintain the biconcave shape of RBCs [32]

In our study, however, 13 C-labelling of lactate was not detectable in human, consistent with previous reports of low conversion of glucose into lactate under normal physiological conditions 11,56

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