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[57] Drugs that strongly inhibit CYP3A4, such as ketoconazole, itraconazole, or certain protease inhibitors, may reduce ondansetron clearance and potentially increase plasma concentrations

Evidence indicates that nuclear factor B (NF-B) signaling can be activated in the peripheral nervous system following BTZ administration ( 3.5 SCs damage, astrocyte activation, and neuronal dysfunction 3.5.1 SCs damage SCs are the primary glial cells in the PNS and play crucial roles in neurodegenerative diseases while promoting nerve regeneration (Taveggia and Feltri, 2022

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These findings are consistent with reports that L-theanine suppresses NF-B signaling and downregulates pro-inflammatory cytokine production 42,43,44

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