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When nutrients are abundant (i.e., when youre eating regularly), mTOR reduces autophagy because the cells have plenty of fuel

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Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, et al 4-hydroxynonenal inhibits SIRT3 via thiol-specific modification Chem Res Toxicol

[PubMed] [PMC] Lyu J, Okada H, Sunagozaka H, Kawaguchi K, Shimakami T, Nio K, Murai K, Shirasaki T, Yoshida M, Arai K, Yamashita T, Tanaka T, Harada K, Takamura T, Kaneko S, Yamashita T, Honda M (2024) Potential utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction-associated steatohepatitis

Several studies have shown increased expression of pro-inflammatory cytokines when plasma TMAO levels were increased