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7.4 Gut microbiota dysbiosis and metabolic-endocrine crosstalk The gradual buildup of abnormal protein aggregates in the central nervous system (CNS) is a key characteristic of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) (129)

Heart palpitations and caffeine sensitivity would mean the person benefits from eating caffeine-free stuff

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Current drugs to treat Alzheimers disease Available FDA approved drugs to treat AD fall into two major classes (Table 1): 1) Namenda (memantine HCl) acts as an N-methyl-D- aspartate (NMDA) receptor antagonist designed to limit glutamate excitotoxicity and resulting neuronal damage [15-17]

Three of the four ACs (C2, C8 and C10) investigated in the present study were not available in the previously described [43] metabolomics dataset