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The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

10.1007/s00018-016-2416-6 324 SaxenaS.CaroniP

Biochem 25 , 623633 (2014)

Patients with certain kidney conditions, heart failure, or active cardiovascular instability may require modified formulas or additional evaluation before treatment