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Whether the mechanisms that play in these exceptional circumstances resemble more closely developmental or adult remyelination is poorly understood

10, 53, 54 More recently, cell-based HTS has identified several classes of potentiators (including tetrahydro-benzothiophenesthio-oxoaminothiazoles and pyrazolepyrroleisoxazole) that, at difference with Ivacaftor, do not reduce the efficacy of F508-del-CFTR correctors 55 and also weakly activate WT and G551D CFTR