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These experiments had been approved by Medical Laboratory Animal Research Institute of Medical Sciences China [Permit Number: SYXK (Jing) 2014-0004]

Introduction Iron overload is a long-standing problem that has aroused great interest in the field of chronic diseases ( Studies on iron overload mainly focus on liver fibrosis, liver cancer ( Recent researches on the treatment of iron overload by flavonoids mainly concentrated on the effect of animal or cell experiments of a single compound, and there was a lack of macroscopic summing up and sorting out from the same kind of compounds