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The results demonstrated that pretreatment with NAC not only significantly increased the activities of GSH and GPX but also reduced the levels of lipid peroxidation in the heart mitochondria of ISO-treated rats [100]

Fernndez et al

This was not the case for the medial frontal cortex nor when an analysis was done including all areas

Galaly SR, Ahmed OM, Mahmoud AM (2014) Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis

In addition, the cytoprotection was independent of the antioxidant status of the catalase and glutathione peroxidase enzymes, suggesting a direct interaction between creatine and oxidant and/or free radicals