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31 Infliximab (not approved for this indication) is given by prolonged infusion every six to eight weeks, with dosing based on body weight

Interestingly, it has also been shown that increased expression of the PD-1/PD-L1 axis suppresses the activity of NK cells, the CD38 mAbs-mediated ADCC [115]

Many patients notice improvements within a few weeks, while others may require a few months for optimal outcomes

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10.1523/JNEUROSCI.0937-11.2011 J