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10.1186/s12943-017-0648-1 150 ZhouJ.LiX

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doi: 10.3390/cells10030540 190 ProcacciniC.SantopaoloM.FaicchiaD.ColamatteoA.FormisanoL.de CandiaP.et al

Although engineered high-fidelity Cas9 variants and base editors have reduced off-target activity, achieving complete specificity remains elusive

By revealing the nuanced role of GPX2 in endoderm progenitor differentiation, we provide unprecedented insights into the molecular mechanisms underlying lineage specification and cellular plasticity