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doi: 10.1007/s00277-002-0560-6

Antioxidant functions of vitamins

Unsteadiness and weakness often develop as the disease advances, affecting mobility and quality of life

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These substances are theorised to enhance hepatic fat metabolism and support liver function

Thus, where genotype is known, there is a strong case for initiating serum vitamin B 12 monitoring from initiation of metformin treatment in people with the AA genotype but deferring this until 10 years of treatment in the rest of the population who have no other risk factors