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BILAG: British Isles Lupus Assessment Group

However, after irradiation, GPx1-KO and wild-type mice exhibited almost similar levels of intestinal GPx activity, and this was due to the radiation-induced compensatory upregulation of GPx2 in GPx1-KO mice

Many synthetic compounds with primary or secondary antioxidant activity have been developed

Indeed elevated levels of ROS (during radio- or chemotherapy) induced the translocation of Nrf-2 to the nucleus, where it bound to the antioxidant response element (ARE) or the electrophile-response element in the promoter region of Nrf-2, targeting antioxidant and anti-apoptotic genes, including heme-oxygenase 1 (HO-1) (Pan et al., 2013

Solution stability of Captisol-stability melphalan (Evomela) versus Propyelene glycol-based melphalan hydrochloride injection

Reactive oxygen species (ROS) generated during normal metabolism and in pathological conditions induce lipid peroxidation with consequent formation of reactive carbonyl species (RCS) such as 4-hydroxytrans-2-nonenal (HNE) that can deplete reductants including glutathione resulting in damage to cellular macromolecules such as lipids, proteins, and nucleic acids eventually culminating in tissue injury