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The consequences are particularly interesting if one looks at the cells that compose the gut wall: when they burn food for energy (rather than fermenting it for building blocks or energy storage), the level of oxygen near the gut wall drops (von Martels et al., 2017), and the microbiota as a whole becomes more anaerobic and healthier (Litvak et al., 2017)

People with known allergies to biotin or those experiencing acne flare-ups from supplementation should also avoid or discontinue use

The Real-World Consequences Let's be blunt

The most consistently recommended practical step, across the community discussion of this topic, is starting at a reduced frequency rather than daily use from the outset: two to three applications a week for the first couple of weeks, building up to daily use gradually rather than all at once

It upregulates vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), stimulates angiogenesis to improve blood supply to damaged tissue, and enhances collagen synthesis at injury sites

The result is a sustained decline in sex steroid hormones, a state sometimes described medically as chemical castration in men or hypogonadism in both sexes