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Isoalantolactone induces cell cycle arrest, apoptosis and autophagy in colorectal cancer cells

10.1016/j.freeradbiomed.2015.06.007 106 RistiA

In zebrafish and nude mouse models of Hep3B tumor transplantation, PL-modified oncolytic viruses not only modulated ROS levels in vivo but also reduced tumor burden more effectively than unmodified viruses, improving the overall physiological state of the treated animals [287]