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To further examine this notion, MPO was knocked down from differentiated HL-60 and 32Dcl3 cells by two different short-hairpin RNA (shRNAs

1 Introduction Apolipoprotein E (ApoE) is a key genetic risk factor in the complex landscape of Alzheimers disease (AD), especially in its late-onset sporadic form

Future studies should investigate whether mitochondria-targeted interventions (e.g., exercise, NAD + precursors, mitophagy inducers) can simultaneously reduce frailty and prevent cardiometabolic-cognitive decline [40]

Acting as a crucial sensor for assessing the nutritional status of eukaryotic cells, mTOR exhibits activation in response to a surplus of amino acid availability, thereby regulating an assortment of synthetic metabolic pathways essential for sustaining cellular growth [157]

Lipid peroxides translocate the BH3 interacting-domain death agonist pro-apoptotic protein (BID), increase membrane porosity, attenuate selective permeability, release organelles into the extracellular medium, and cause ferroptosis [9]

Lyophilized forms maintain stability for 12-18 months at proper temperatures