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HIF-1 lies upstream of vascular endothelial growth factor (Hu et al., 2016), which itself is directly (or indirectly via HIF-1) induced by copper (Sen et al., 2002)

JAs also control gene activation in response to abiotic and biotic stressors by promoting defensive mechanisms

Structural basis for rational design of inhibitors targetingTrypanosoma cruzisterol 14-demethylase: Two regions of the enzyme molecule potentiate its inhibition