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Supplementary material The Supplementary Material for this article can be found online at: Glossary TNF- tumor necrosis factor- IL interleukin ROS reactive oxygen species PAMPs pathogen associated molecular patterns DAMPs damage/danger associated molecular patterns TLRs toll like receptors NF-B nuclear factor kappa light chain enhancer of activated B- cells OXOPHOS oxidative phosphorylation MCT-1 monocarboxylate transporter-1 MCT-4 monocarboxylate transporter-4 LDHA lactate dehydrogenase-A LDHB lactate dehydrogenase-B GLUT-1 glucose transporter-1 GLUT-3 glucose transporter-4 HIF-1 hypoxia inducible factor-1 HIF-1 hypoxia inducible factor-1 PHD-2 prolylhydroxylase-2 ODDD oxygen dependent degradation domain pVHL Von-hippel-Lindau tumor repressor protein FIH-1 factor inhibiting hypoxia inducible factor 1 CBP CREB binding protein CTAD C- terminal transactivation domain HRE hypoxia response element 2-OG 2- oxoglutarate TCA tricarboxylic Acid cycle IB inhibitor of nuclear factor kappa B IKK inhibitor of nuclear factor kappa-B kinase NEMO NF-B essential modulator MEFs mouse embryonic fibroblasts TAK-1 transforming growth factor -- activated kinase-1 SCF SKP1-cullin-1-F- box protein TrCP beta transducing repeats containing protein VEGF vascular endothelial growth factor MMPs matrix metalloproteinases CAFs cancer associated fibroblasts ECM extracellular matrix CXCl-2 C-X-C motif chemokine ligand 2 SDF-1 stromal cell-derived factor - 1 c-myc cellular myelocytomatosis oncogene CXCR4 C-X-C chemokine receptor type 4 bHLH basic helix loop helix PAS PER-ARNT-SIM ARNT aryl hydrocarbon receptor nuclear translocator ATP adenosine triphosphate ETC electron transport chain PDK-1 pyruvate dehydrogenase kinase-1 IDH-1 isocitrate dehydrogenase-1 IDH-2 isocitrate dehydrogenase-2 ACO-1/2 aconitase-1/2 ACl ATP- citrate lyase ACC acetyl CoA carboxylase FASN fatty acid synthase SREBP-1 sterol regulatory element binding protein-1 PPAR peroxisome proliferator receptor- FABP fatty acid binding protein LRP-1 lipoprotein receptor related protein VLDLR very low density lipoprotein receptor TAGs Triacylglycerols AGPAT2 acylglycerol-3-phosphate acyl transferase-2 DAG diacylglycerol NHE1 sodium hydrogen exchanger-1 Ca9 carbonic anhydrase-9 BAFFR B-cell activating factor receptor CD cluster of differentiation RANK receptor activator of nuclear factor B TNFR2 tumor necrosis factor receptor 2 FN14 fibroblast growth factor-inducible 14 TWEAK tumour necrosis factor (TNF)-like weak inducer of apoptosis References 1 AckermanD.SimonM

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PINK1 is a kinase which functions as a mitochondrial damage sensor and initiates mitochondrial quality control by accumulating on the damaged organelle