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J Neurosci 15(5 Pt 1):33283341 Baumgartner U, Buchholz HG, Bellosevich A, Magerl W, Siessmeier T, Rolke R et al (2006) High opiate receptor binding potential in the human lateral pain system

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Strong mitochondrial activity is also important because follicle cells require significant energy to produce keratin and sustain rapid cell division

Although these studies utilize different AAV serotypes, promoters, and administration routes, they consistently demonstrate sustained therapeutic efficacy without any significant safety concerns