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NAFLD, mitochondrial dysfunction, chronic inflammation, insulin resistance

(2019) Melatonin improves in vitro development of vitrified-warmed mouse germinal vesicle oocytes potentially via modulation of spindle assembly checkpoint-related genes

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It is interesting to consider that there are catalytic domain HCU mutations that result in a CBS enzyme with normal basal activity but non-responsive to SAM 41

Its unique chemical makeup is what allows it to slip through cell membranes and interact directly with the NNMT enzyme

In: Sarafoglou K, Hoffmann GF, Roth KS (eds) Pediatric endocrinology and inborn errors of metabolism, 2e