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Once it enters the cytoplasm, a part of Cu + binds to glutathione (GSH) and is delivered to metallothionein 1/2 (MT1/2) to be restored, and other parts of Cu + are either transferred to the nucleus or ATP7A/7B located in the trans-Golgi network (TGN) by the chaperone antioxidant-1(ATOX1) to facilitate the synthesis of cuproenzymes (Lutsenko et al., 2007) or delivered to superoxide dismutase 1 (SOD1) in the cytoplasm and mitochondrial intermembrane space by a copper chaperone for superoxide dismutase (CCS) to detoxify reactive oxygen species (ROS)

CrossRef The Role of Polyphenols in Regulating Skeletal Muscle Development and Homeostasis: Molecular Mechanisms and Potential Medical Applications Roberto Mattioli, Daniel Di Risola, Carmen Chiaradia, Ivan Dimauro, Luciana Mosca, Guglielmo Duranti, Roberta Ceci Molecular Nutrition & Food Research.2026;[Epub] CrossRef PDK4 knockdown suppresses osteoclast differentiation in osteoporosis through glycolytic flux suppression and AMPK activation Yanling Huang, Rong Zhou, Rulian Liang, Jiping Shen Bone.2026

Acknowledgements We thank Yale School Medicine, Yale West Campus, Systems Biology Institute and Cancer Biology Institute for the instrumentation supports

This condition manifests as flat brownish or blue-grey patches, primarily on the face, predominantly affecting women

3.1 Overview of targeted signaling pathways of natural products The NPs exhibit therapeutic potential in IPF by modulating key signaling pathways involved in inflammation, myofibroblast activation, oxidative stress, and ECM deposition

Trends in Cardiovascular Medicine, 25 (6), 475484