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Phase I Study of SYNB1891, an Engineered E

Cell Mol Neurobiol 37:13191324

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Studies have revealed that IF increases microbial diversity, particularly enriching beneficial taxa such as Bifidobacteria and Akkermansia muciniphila , which are crucial for maintaining gut barrier integrity, reducing intestinal permeability, and supporting systemic metabolic health [80]

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However, transformation with the editing plasmid resulted in severe growth inhibition, rendering the deletion of Lp_0018 unsuccessful (Supplementary Fig