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Short brain-active peptide comparison Peptide Pinealon Sequence Glu-Asp-Arg (3 aa) Primary research focus Neuroprotection, cognition, oxidative-stress endpoints Common route Oral or subcutaneous Peptide Epitalon Sequence Ala-Glu-Asp-Gly (4 aa) Primary research focus Pineal gland, telomerase, longevity endpoints Common route Subcutaneous Peptide Semax Sequence ACTH(4-7) analog (7 aa) Primary research focus Cognition, focus, neuroprotection Common route Intranasal Peptide Selank Sequence Tuftsin analog (7 aa) Primary research focus Anxiety, cognition, immune modulation Common route Intranasal These are not interchangeable

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Johnson MB, Young AD, Marriott I (2017) The therapeutic potential of targeting substance P/NK-1R interactions in inflammatory CNS disorders

Functional interaction between FOXO3a and ATM regulates DNA damage response

50 , W165W174 (2022)