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Overall, our results propose a novel therapeutic strategy for APAP-induced liver injury, involving hepsin administration alongside a low dose of NAC to improve treatment effectiveness and address current limitations

Theophylline and theobromine have distinct physiological effects

Data availability Data is available upon reasonable request, numerical source data for graphs in the manuscript can be found in the supplementary data file (Supplementary Source Data 1)

This was also the case when salmon were fed fish protein hydrolysates, which is a protein source rich in taurine, resulting in reduced relative liver size and reduced visceral fat mass [54]

Metabolomics APAP-induced liver injury biomarkers summary It is well established that translation of metabolic biomarkers from animal studies to humans is challenging due to the species difference as well as the confounding factors in humans including diet, age, lifestyle, overall health, drugdrug interaction and others, all of which will influence the metabolome profile