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doi: 10.3390/ijms22115427

Nedelec T Article: CLIMATE OF THE PAST

The US FDA New Drug Approvals in November 2025 Shots: Innovation surged in November, with cutting-edge science and strategic collaborations reshaping the drug development landscape across oncology, renal disease, hereditary conditions, and more The US FDA cleared five standout therapies, including Bayers Hyrnuo (Sevabertinib), UCBs Kygevvi (Doxecitine + Doxribtimine), and Arrowheads Redemplo, underscoring a month of meaningful clinical progress November 2025 closed with five approvals, matching last years total, signaling sustained momentum and a steady flow of breakthrough treatments entering the market Company: UCB Product: Kygevvi Active Ingredient: Doxecitine + Doxribtimine Disease: Thymidine Kinase 2 Deficiency Date: Nov 03, 2025 Shots: FDA has approved Kygevvi (2g/2g

As emphasized throughout this review, astrocytes play fundamental roles in the CNS and neurodegeneration

10.1093/hmg/ddt516 36 XuY.GongB.YangY.AwasthiY

Adv Neurol 91:133142