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The important caveat is that all of them come from in vitro cell studies or animal models not human beings

Figure 8 To conclude, macrocyclizations by oxidative disulfide formations in the N-terminal of Ang IV analogues or alternatively displacement of the disulfide unite with a trans double bond can provide very potent inhibitors of IRAP, as exemplified with 23 (HA08) comprising a 13-membered ring system and 28 , 30 , and 32 comprising 14-membered ring systems

Why the Combination Works The molecular synergy between these peptides creates effects exceeding what either achieves alone

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(eds) Cancer Cell Metabolism: A Potential Target for Cancer Therapy