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Dysregulation of this pathway through altered dimerization, post-translational modifications, or impaired regulation contributes to the pathophysiology of Alzheimers disease, Parkinsons disease, Huntingtons disease, and amyotrophic lateral sclerosis, leading to protein aggregation, mitochondrial dysfunction, and neuroinflammation

Burns et al

The specific molecular mechanisms by which ROS is depleted are unclear, however, the decline in lipid peroxidation levels alleviates ferroptosis

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Rb accounts for approximately 2% to 3% of pediatric tumors (286)