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The ED 50 for this effect is 0.25 2.5 ng/mL

[DOI] [PubMed] [Google Scholar] 49.Marelli D., Paul A., Samson R., et al

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The evolving landscape of obesity pharmacotherapy Nature Reviews Drug Discovery, 2026 1 Obesity pharmacotherapy has moved from weight loss drugs to cardiometabolic disease-modifying therapy Obesity is now framed as a chronic, relapsing, neuroendocrine-metabolic disease, not simply a lifestyle failure