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In a recent study Sheikh Abdur Rashid et al., prepared methotrexate-loaded almond oil-based nanoemulsion formulation by applying high shear homogenization technique for PsO treatment

Neural tissue cannot tolerate prolonged oxidative stress the way slower-metabolizing tissues can

However, the absence of long-term data means exercising appropriate caution with extended use

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This matters because even a small impurity or inconsistency in formulation can affect how the peptide works in the body and may increase the risk of unwanted side effects

Similarly, walking distance improved modestly in the prolotherapy group at T3 and T4 follow-up, but the gains were not maintained long-term, and overall functional outcomes remained inferior to the mechanical needling group throughout the study period [63]