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3 At first blush, the findings might seem so clinically intuitive that they hardly merit study

4.3 Biomarker development and patient stratification based on metabolic pathways Multi-omics stratification is being formed: integrated analysis of transcriptomelipidomeimmune infiltration reveals that there is a coupling relationship between the strength of lipid metabolic gene pathway and CD8 + T cell infiltration/function, and survival outcome, which can be used to guide the priority of metabolism-immune combination (Simeth et al., 2025)

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65 While glutamine is an important regulator of mTORC1, T cells are particularly sensitive to leucine availability