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For severe sagging, surgery is still the best option

Conversely, some studies show that a deficiency in vitamin B12 may cause appetite loss, potentially leading to weight loss if left untreated ( If youre low or deficient in B12, your healthcare provider will likely recommend oral vitamin B12 supplements or injections to increase your blood levels ( summary Low levels of vitamin B12 can cause megaloblastic anemia, which is characterized by shortness of breath, headaches, and fatigue

Journal of Bioscience and Bioengineering, 127 (2), 183189

Yakovlev, P

Phenotypes in male X-ALD patients Cerebral Adrenoleukodystrophy (cALD) cALD is the most rapidly progressive phenotype of X-ALD occurring in children (3540%) aged 212 years and characterized by sudden inflammatory progressive intellectual, psychic, visual, and gait disturbances