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Furthermore, a key limitation of oral administration is the off-target effect, where most of the drugs may act on peripheral organs before they can reach the CNS

In addition, coppers regulatory effect on angiogenic factors such as fibroblast growth factor (FGF) and interleukin-1 alpha (IL-1) is also crucial, as the secretion of these factors requires the involvement of copper-dependent multi-protein complexes (96, 97)