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The translation of Se-based nanotechnology into clinical applications requires not only the development of safe, simple, sustainable, and cost-effective methods for the synthesis of SeNPs, but also a thorough understanding of their relevant physicochemical and biological properties that, in turn, might impact their in vitro and in vivo effects, safety control mechanisms, pharmacokinetics and pharmacodynamics, and potential biomedical applications

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These effects were associated with the inhibition of NF-B nuclear translocation and reduced phosphorylation of B and mitogen-activated protein kinases, including p38, extracellular signal-regulated kinases 1 and 2 (Erk 1/2), and c-Jun N-terminal kinase (282)

Halasa, Eileen J

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FLAG-M2 (monoclonal mouse anti-Flag M2, F3165, Sigma Aldrich) was immobilized on the sensor chip (GLC, Bio-Rad) by amine coupling chemistry, whereas an activated/deactivated empty surface was prepared in a parallel lane of the same chip and used as reference